I guess everyone has experienced pain at least once, and does not like it. But keep in mind, that pain states an alert, if something is not right. For example, last time I did not notice that I burned my finger!
Pain is described as an unpleasant sensory and emotional experience associated with potential or actual tissue damage. It is chronic if it persists for more than 3 months [IASP, International Association for the Study of Pain].
origin of pain …
[Dept. of Mol. Physiology – University of Heidelberg, 2008]
The biochemical origin of pain is inflammation and the inammatory response [S.Omoigui, Medical Hypotheses 6:69, 2007]. Still, pain is a complex interaction, including the aspects of emotional and behavioural factors [M.Serpell, Anaesthesia & intensive care medicine 6:1, 2005]. Noxa is anything that exerts a harmful influence. Nociceptors can be described as pain cells. They induce the perception of a painful stimulus / noxae signals. The nociceptive system describes the sense of pain as a discrete sensory perception, which is induced by noxae [R.F.Schmidt, Pharmazie in unserer Zeit 1:31, 2002]. Nociception is conveyed from the periphery to the brain by an adaptable and dynamic pathway, which is transmitted and modulated at three levels, peripheral (detection by receptors), spinal (transmission by the nerves), supraspinal (interpretation by the brain) [M.Serpell, Anaesthesia & intensive care medicine 6:1, 2005]. The sensory endings of nociceptors usually respond to very strong stimuli. The stimulus acts on a transduction channel, opens it and causes depolarization and electrical excitation of the neuron. In the nervous system, afferent neurons, otherwise known as sensory or receptor neurons, carry nerve impulses from receptors or sense organs toward the central nervous system.
New medicines …
In order to combat severe or persistent nociceptive or neuropathic pain, research is based on: inammatory mechanisms, nerve synapse receptors, ion channels involved in the transmission of nerve impulses [ABPI, The Association of the British Pharm. Ind., 2004].